Whipple Disease Symptoms | Medical Algorithm

Are you evaluating a patient with an unexplained illness?

Yes

Does the patient have?

• fever with night sweats?

Yes

• fatigue?

Yes

• unintended weight loss?

Yes

• elevated ESR and/or serum C-reactive protein?

Yes

• migratory polyarthritis?

Yes

• unexplained anemia?

Yes

• skin pigmentation?

Yes

• lymphadenopathy with noncaseating granulomas?

Yes

• unexplained uveitis

Yes

• myoclonus?

Yes

• dementia?

Yes

• supranuclear opthalmoplegia?

Yes

• malabsorption syndrome?

Yes

• small bowel or other biopsy showing macrophages with PAS-positive diastase resistant granules?

Yes

• pulmonary hypertension?

Yes

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Specialty

Objective

ICD-10

Clinical Features of Whipple's Disease

Purpose: To evaluate a patient with an unexplained illness for features that could suggest the presence of Whipple's disease.