2010 AJCC Staging System for Cutaneous Squamous Cell Carcinoma

The American Joint Committee on Cancer (AJCC) revised its staging system for cutaneous squamous cell carcinoma in 2010.

Parameters:

(1) greatest dimension in centimeters

(2) number of risk factors

(3) invasion into orbit, maxilla, mandible and/temporal bones

(4) invasion into other bones

(5) direct perineural invasion of skull base

Risk factors:

(1) thickness > 2 mm

(2) Clark level 4 or 5 (into mid-deep reticular dermis or into subcutaneous fat)

(3) perineural invasion

(4) primary site in ear or non-hair bearing lip

(5) poorly differentiated

Greatest Dimension	Number of Risk Factors	Invasion into Specific Structures	Stage
<= 2 cm	0 or 1	none	T1
<= 2	>=2	none	T2
> 2 cm	NA	none	T2
NA	NA	obit, maxilla, mandible, temporal	T3
NA	NA	other bone and/or direct perineural invasion of skull base	T4

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