Grogan et al reported a simple staging system for wild type transthyretin (ATTRwt) cardiac amyloidosis. The authors are from Mayo Clinic.
Patient selection: wild-type transthyretin cardiac amyloidosis
Parameters:
(1) serum troponin T in ng/mL
(2) serum NT-proBNP in pg/mL
|
Parameter
|
Finding
|
Points
|
|
serum troponin T
|
<= 0.05 ng/mL
|
0
|
|
|
> 0.05 ng/mL
|
1
|
|
serum NT-proBNP
|
<= 3,000 pg/mL
|
0
|
|
|
> 3,000 pg/mL
|
1
|
total score =
= SUM(points for both parameters)
Interpretation:
• minimum score: 0
• maximum score: 2
|
Total Score
|
Grade
|
4-Year Overall Survival
|
|
0
|
I
|
57%
|
|
1
|
II
|
42%
|
|
2
|
III
|
18%
|
Performance:
• The C-statistic is 0.74.
Other factors impacting mortality:
(1) older age
(2) low ejection fraction
(3) pericardial effusion
