The International AIH Pathology Group reported criteria for the histologic criteria for autoimmune hepatitis. Criteria were given for both portal and lobular hepatitis. The authors are from multiple institutions from Europe, the United States and Australia.
Specimen: liver biopsy
Parameters:
(1) portal inflammation
(2) interface hepatitis
(3) lobular inflammation
(4) histologic features suggesting another diagnosis
Portal Inflammation
Interface Hepatitis
Lobular Inflammation
Another Diagnosis
Portal AIH
lympho-plasmacytic(LP)
moderate to severe
NA
no
likely
lympho-plasmacytic
NA
moderate to severe
no
likely
lympho-plasmacytic
none to mild
none to mild
no
possible
lympho-plasmacytic
moderate to severe
NA
yes
possible
lympho-plasmacytic
NA
moderate to severe
yes
possible
inflammation not LP
none to mild
none to mild
yes
unlikely
none
NA
NA
NA
unlikely
If the portal inflammation is not lymphoplasmacytic, then the diagnosis is always unlikely by the above table.
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