A variety of features found in patients with myelodysplasia can be used to separate those who will have a fairly good prognosis from those who will have a poor one.
Finding
Good
Poor
patient's age
younger
elderly
neutrophil and platelet counts
normal to moderately reduced
severe neutropenia and/or thrombocytopenia
blasts in bone marrow
< 20%
20-29% (>= 30% indicates acute leukemia)
blasts in blood
absent
increased
Auer rods in blasts
absent
present
ringed sideroblasts
present
absent
chromosomal abnormalities
normal, or mixed with no complex abnormalities
mostly abnormal or complex abnormalities
in vitro bone marrow culture
nonleukemic growth pattern
leukemic growth pattern
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