Rarely a patient may present with adrenal insufficiency following a vaccination.
The adrenal insufficiency may be gradual, or it may present as an acute adrenal crisis.
Occurrence:
(1) COVID-19 vaccines
(2) tetanus
(3) polio
(4) pertussis
One subset of patients have pre-existing panhypopituitarism and/or adrenal insufficiency.
Another subset has the onset of hypopituitarism and/or adrenal insufficiency after the vaccination. These may result from acute hemorrhage that is a consequence of thrombotic thrombocytopenia.
If a patient with pre-existing subacute adrenal insufficiency develops an acute infection or metabolic stress and if the patient develops severe signs and symptoms, then the stress could precipitate adrenal insufficiency.
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