Description

The Combined Clinical and Laboratory Index (CCLI) is a global score of alcoholic liver disease severity derived from a series of combined clinical and laboratory measurements commonly used to assess liver disease. The initial version was proposed in 1979, and was later revised in 1983.


Clinical Parameters

 

Parameter

Finding

Points

hepatomegaly

present

1

 

absent

0

splenomegaly

present

1

 

absent

0

ascites

0

0

 

1+

1

 

2+

2

 

3+

3

encephalopathy

absent

0

 

Grade I

1

 

Grade II

2

 

Grade III

3

bleeding tendency (clinical)

present

1

 

absent

0

spider nevi

present

1

 

absent

0

palmar erythema

present

1

 

absent

0

collateral circulation

present

1

 

absent

0

peripheral edema

present

1

 

absent

0

anorexia

present

1

 

absent

0

weakness

present

1

 

absent

0

 

where:

• hepatomegaly = liver palpable more than 3 cm below costal margin

 

Clinical Finding

Definition

Grade

ascites

abdominal distension, shifting dullness, flank dullness, and/or bulging, fluid wave and/or puddle sign

+1

 

obvious distention of abdomen

+2

 

very tense ascites with intra-abdominal organs not palpable

+3

encephalopathy according to Adams and Foley (1949)

clouded consciousness and impaired orientation with mild restlessness or agitation

I

 

drowsiness to stupor

II

 

deep coma

III

 

Laboratory Parameters

 

Parameter

Finding

Points

serum SGOT (AST)

> 20 U

1

 

<= 20 U

0

serum GGT

<= 100 U

0

 

101-200 U

1

 

> 200 U

2

serum alkaline phosphatase

<= 80 U

0

 

> 80 U

1

serum albumin

>= 2.59 g/dL

0

 

< 2.59 g/dL

1

(patient prothrombin time) - (prothrombin time control)

<= 0

0

 

0.1 - 3.0 seconds

1

 

3.1 - 5.0 seconds

2

 

> 5.0 seconds

3

serum bilirubin

< 1.2 mg/dL

0

 

1.2 - 2.0 mg/dL

1

 

2.1 - 5.0 mg/dL

2

 

> 5.0 mg/dL

3

 

CCLI =

= SUM(clinical parameters) + SUM(laboratory parameters)

 

normalization rate =

= ((previous CCLI) - (lowest CCLI)) / (number of days between two estimates) * 100

 

Interpretation:

• minimum score: 0

• maximum score: 15 (clinical) + 11 (laboratory) = 26

 


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