The Combined Clinical and Laboratory Index (CCLI) is a global score of alcoholic liver disease severity derived from a series of combined clinical and laboratory measurements commonly used to assess liver disease. The initial version was proposed in 1979, and was later revised in 1983.
Clinical Parameters
Parameter |
Finding |
Points |
---|---|---|
hepatomegaly |
present |
1 |
|
absent |
0 |
splenomegaly |
present |
1 |
|
absent |
0 |
ascites |
0 |
0 |
|
1+ |
1 |
|
2+ |
2 |
|
3+ |
3 |
encephalopathy |
absent |
0 |
|
Grade I |
1 |
|
Grade II |
2 |
|
Grade III |
3 |
bleeding tendency (clinical) |
present |
1 |
|
absent |
0 |
spider nevi |
present |
1 |
|
absent |
0 |
palmar erythema |
present |
1 |
|
absent |
0 |
collateral circulation |
present |
1 |
|
absent |
0 |
peripheral edema |
present |
1 |
|
absent |
0 |
anorexia |
present |
1 |
|
absent |
0 |
weakness |
present |
1 |
|
absent |
0 |
where:
• hepatomegaly = liver palpable more than 3 cm below costal margin
Clinical Finding |
Definition |
Grade |
---|---|---|
ascites |
abdominal distension, shifting dullness, flank dullness, and/or bulging, fluid wave and/or puddle sign |
+1 |
|
obvious distention of abdomen |
+2 |
|
very tense ascites with intra-abdominal organs not palpable |
+3 |
encephalopathy according to Adams and Foley (1949) |
clouded consciousness and impaired orientation with mild restlessness or agitation |
I |
|
drowsiness to stupor |
II |
|
deep coma |
III |
Laboratory Parameters
Parameter |
Finding |
Points |
---|---|---|
serum SGOT (AST) |
> 20 U |
1 |
|
<= 20 U |
0 |
serum GGT |
<= 100 U |
0 |
|
101-200 U |
1 |
|
> 200 U |
2 |
serum alkaline phosphatase |
<= 80 U |
0 |
|
> 80 U |
1 |
serum albumin |
>= 2.59 g/dL |
0 |
|
< 2.59 g/dL |
1 |
(patient prothrombin time) - (prothrombin time control) |
<= 0 |
0 |
|
0.1 - 3.0 seconds |
1 |
|
3.1 - 5.0 seconds |
2 |
|
> 5.0 seconds |
3 |
serum bilirubin |
< 1.2 mg/dL |
0 |
|
1.2 - 2.0 mg/dL |
1 |
|
2.1 - 5.0 mg/dL |
2 |
|
> 5.0 mg/dL |
3 |
CCLI =
= SUM(clinical parameters) + SUM(laboratory parameters)
normalization rate =
= ((previous CCLI) - (lowest CCLI)) / (number of days between two estimates) * 100
Interpretation:
• minimum score: 0
• maximum score: 15 (clinical) + 11 (laboratory) = 26
Purpose: To use the initial Combined Clinical and Laboratory Index (CCLI) from 1979 to assess the severity of alcoholic liver disease.
Specialty: Gastroenterology, Toxicology
Objective: clinical diagnosis, including family history for genetics, laboratory tests, disease progression
ICD-10: K70.9,