Guaraldi et al reported an algorithm for classifying pituitary adenomas (pituitary neuroendocrine tumors). The authors are from the University of Bologna, Bellaria Hospital and IRCCS Instituto dells Scienze Neurologische at Bologna.
Patient selection: pituitary adenoma (pituitary neuroendocrine tumor)
Prognostic factors
(1) higher Trouillas grade (Grade 2 or 3)
(2) > 2 mitoses per 10 high power fields (hpf)
(3) >= 3% Ki-67 staining
(4) p53 expression
(5) tumor invasion
(6) ACTH subtype
Trouillas Grade
Hormone Staining
Node (Classification Tree Analysis)
1a
GH, PRL, FSH/LH
3
2a
4
1b, 2b, 3
5
ACTH
6
1b, 2a, 2b, 3
7
Node
Progression
4.3%
10.2%
26.8%
12.4%
31.7%
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