Horvat et al used serum C-reactive protein and serum ferritin to triage pediatric patients with sepsis into prognostic groups. The authors are from multiple institutions in the United States.
Patient selection: >= 44 weeks and <= 18 years old
Initial serum testing: 24 hours or more of sepsis onset
Parameters:
(1) serum C-reactive protein (CRP) in mg/dL (reference range not stated)
(2) serum ferritin in ng/mL (reference range not stated)
Serum CRP
Serum Ferritin
Group
normal
normal (median 66.4 ng/mL)
1
initially high (median 4 mg/dL) then normal (< 1 mg/dL)
normal (median 115 ng/mL)
2
initially high then falls
high (median 908 ng/mL)
3
very high (median 16 mg/dL)
normal to slight elevation (median 300 ng/mL)
4
very high (median 17 mg.dL)
very high (median 4,058 ng/mL)
5
The groups corresponded to cytokine profiles performed on the patient.
Group
Mortality
1
0%
2
5%
3
6%
4
11%
5
40%
Cutoffs to use for implementation (approximated from Supplement)
CRP
Concentration
normal
<= 1 mg/dL
high
> 1 and <= 9
very high
> 9 mg/dL
Ferritin
Concentration
normal
<= 200 ng/mL
mild elevation
<= 500 ng/mL
high
> 500 ng/mL, < 2,000
very high
>= 2,000 ng/mL
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