Liu et al developed a panel of immunohistochemical stains to distinguish different types of renal cell tumors. The authors are from Beijing Friendship Hospital I Beijing.
Stains employed:
(1) vimentin
(2) CD117
(3) GST-alpha (glutathione S-transferase alpha)
(4) CK7
(5) EpCAM (epithelial cell adhesion molecule)
(6) Hale colloidal iron
Tumors considered:
(1) clear cell renal cell carcinoma (RCC)
(2) chromophobe renal cell carcinoma
(3) oncocytoma
Stain
Clear Cell RCC
Chromophobe RCC or Oncocytoma
vimentin
positive
negative
CD117
negative
positive
GST-alpha
positive
negative
where:
• Clear cell RCC are also oil red O positive.
Stain
Chromophobe RCC
Oncocytoma
Hale colloidal iron
positive in cytoplasm
negative or some staining of membranes
CK7
diffuse
negative or focal
EpCAM
diffuse membrane staining most cells
negative, membranes of single cells or small cell clusters
To read more or access our algorithms and calculators, please log in or register.
