Gulen et al reported a risk assessment tool for anaphylaxis in a patient with systemic mastocytosis. The authors are from Karolinska University and Brigham and Women's Hospital.
Patient selection: systemic mastocytosis
Parameters:
(1) sex
(2) mastocytosis in the skin (MIS)
(3) baseline serum tryptase concentration
(4) atopy
(5) total serum IgE level
Parameter
Finding
Points
sex
male
1
female
0
mastocytosis in the skin
MIS absent
3
MIS present
0
serum tryptase
< 40 ng/mL
2
>= 40 ng/mL
0
atopy
absent
0
present
1
serum IgE
< 15kU/L
0
>= 15kU/L
3
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 10
• A score <= 2 is associated with a low probability of anaphylaxis.
• A score >= 3 is associated with a high probability of anaphylaxis.
Performance:
• The area under the ROC curve is 0.81. The sensitivity was 86% and specificity 54%.
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