Rare strains of Neisseria meningitidis serogroup Y have been identified with antibiotic resistance. It is important to perform antibiotic susceptibility on clinical isolates.
Resistance may consist of one or both of the following:
(1) beta-lactamase
(2) ciprofloxacin resistance
Presentation:
(1) prophylaxis failure
(2) treatment failure
(3) local outbreak
(4) resistance on drug-susceptibility testing
Ceftriaxone and cefotaxime may be used for empiric therapy prior to the availability of susceptibility test results.
For prophylaxis, azithromycin, a single injection of ceftriaxone or a 2-day course of rifampin may be effective.
Vaccination against Neisseria meningitidis may reduce spread of the resistant strain
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