Antioxidant Gap

 

antioxidant gap =

= (serum total antioxidant activity in mmol/L) - (0.69 * (serum albumin in mmol/L)) - (uric acid in mmol/L)

 

where:

• The molecular weight of albumin is 66,460 daltons. 1 g/dL = 0.15046 mmol/L; 1 g/L = 0.015046 mmol/L.

• The Trolox equivalent antioxidant capacity (TEAC) for albumin is 0.69.

• The molecular weight for uric acid is 168.11 daltons. 1 mg/dL = 0.059485 mmol/L.

• The Trolox equivalent antioxidant capacity (TEAC) for uric acid is 1.

• Total antioxidant activity was measured using the ferrylmyoglobin/ABTS assay.

 

change in antioxidant gap =

= (initial antioxidant gap) - (final antioxidant gap)

 

Interpretation:

• A decline in the antioxidant gap (positive change) following myocardial infarction is associated with a higher mortality.