Description

Maehira et al reported a model for predicting post-hepatectomy liver failure based on preoperative parameters. The authors are from Shiga University in Japan.


APART is derived from alanine aminotransferase, prothrombin time activity and remnant liver proportion.

 

Patient selection: major hepatectomy

 

Parameters:

(1) serum ALT in IU/L

(2) prothrombin time activity in percent, from 63 to 121 percent

(3) future remnant liver proportion

 

points for ALT =

= (0.444 * (ALT)) - 3.111

 

points for prothrombin time activity =

= 92.002 - (0.760 * (PT activity))

 

points for future remnant liver proportion =

= 56.570 - (0.666 * (remnant))

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 183.1

 

value of X =

= (0.1 * (score)) - 6.177

 

probability of post hepatectomy liver failure =

= 1 / (1 + EXP((-1) * X))

 

Performance:

• The area under the ROC curve is 0.89.


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