Maehira et al reported a model for predicting post-hepatectomy liver failure based on preoperative parameters. The authors are from Shiga University in Japan.
APART is derived from alanine aminotransferase, prothrombin time activity and remnant liver proportion.
Patient selection: major hepatectomy
Parameters:
(1) serum ALT in IU/L
(2) prothrombin time activity in percent, from 63 to 121 percent
(3) future remnant liver proportion
points for ALT =
= (0.444 * (ALT)) - 3.111
points for prothrombin time activity =
= 92.002 - (0.760 * (PT activity))
points for future remnant liver proportion =
= 56.570 - (0.666 * (remnant))
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 183.1
value of X =
= (0.1 * (score)) - 6.177
probability of post hepatectomy liver failure =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.89.