Hlavaty et al used the Apoptotic Pharmacogenetic Index (API) to predict response to infliximab therapy by a patient with Crohn's disease. The components of the API are associated with the apoptotic response of immune cells to infliximab therapy. The authors are from University Hospital Gasthuisberg in Leuven, Belgium, and University Hospital Bratislava in Slovakia.
Polymorphisms included:
(1) Fas ligand at 843
(2) Fas at 670
(3) Caspase9 at 93
Parameter |
Polymorphism |
Points |
Fas ligand 843 |
TT |
0 |
|
CT |
1 |
|
CC |
1 |
Fas 670 |
GG |
0 |
|
AG |
1 |
|
AA |
1 |
Caspase9 93 |
TT |
0 |
|
CT |
0 |
|
CC |
1 |
apoptotic pharmacogenetic index =
= SUM(points for all 3 ligands)
Interpretation:
• minimum API: 0
• maximum API: 3
• The higher the API the greater the improvement for a patient with Crohn's disease following the first infusion of infliximab.
Specialty: Toxicology, Emergency Medicine, Critical Care, Genetics
ICD-10: ,