Regierer et al reported the B2 Prognostic Index (B2PI) for predicting the outcome for a woman with metastatic breast cancer. The authors are from multiple institutions in Germany.
Patient selection: metastatic breast cancer
Parameters:
(1) metastasis-free interval in years
(2) hormone receptor status
(3) liver metastasis
(4) malignant effusion
(5) brain metastasis
(6) bone metastases
(7) bone marrow metastasis
(8) soft tissue metastasis
(9) lung metastasis
Parameter
Finding
Points
metastasis-free interval
<= 2 years
3
> 2 years
0
hormone receptor status
negative
8
positive
0
liver metastasis
absent
0
present
7
malignant effusion
absent
0
present
4
brain metastasis
absent
0
present
8
bone metastasis
absent
0
present
4
bone marrow metastasis
absent
0
present
10
soft tissue metastasis
absent
0
present
4
lung metatasis
absent
0
present
4
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 52
Total Score
Risk Group
5-Year Survival
<= 8
low
41%
9 to 14
intermediate
27%
>= 15
high
10%
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