Amarenco et al reported the B2LEED3S score for predicting intracranial bleeding following ischemic stroke in a patient receiving antiplatelet therapy. The authors are from multiple institutions in Europe.
Patient selection: non-cardioembolic ischemic stroke in a patient on antiplatelet therapy
Parameters:
(1) body mass index (B)
(2) blood pressure (B)
(3) lacune small vessel disease (L)
(4) elderly (E)
(5) ethnicity (E)
(6) cardiovascular disease (D)
(7) cerebrovascular disease (D)
(8) dual antithrombotic or anticoagulant therapy (D)
(9) sex (S)
Parameter
Finding
Points
BMI
< 25 kg per square meter
1
>= 25
0
blood pressure
high
2
normal or low
0
small vessel disease
no
0
yes
1
age
< 75 years
0
>= 75 years
1
ethnicity
Asian
2
other
0
cardiovascular disease
no
0
yes
2
cerebrovascular disease
no
0
yes
2
dual therapy
no
0
yes
1
sex
female
0
male
1
total score =
= SUM(points for all 9 parameters)
Interpretation:
• minimum score: 0
• maximum score: 13
• The higher the score the greater the risk for intracranial hemorrhage (ICH).
Score
2-Year Risk ICH
0 or 1
0.7%
2
0.9%
3
1.2%
4
1.5%
5
1.9%
6
2.4%
7
3.0%
8
3.8%
9 to 13
5.2%
Performance:
• The area under the ROC curve is 0.58 for validation group and 0.64 for derivation set.
To read more or access our algorithms and calculators, please log in or register.
