Shireman et al developed a model for predicting the risk of bleeding for an elderly patient being treated with warfarin. This can help identify a patient who may benefit from closer monitoring during anticoagulant therapy. The authors are from the University of Kansas and University of Iowa.
Patient selection: patients with atrial fibrillation, typically > 65 years of age
Parameters:
(1) age of the patient in years
(2) gender
(3) history of remote bleeding
(4) history of recent bleeding
(5) alcohol and/or drug abuse
(6) diabetes mellitus
(7) anemia
(8) therapy with an antiplatelet agent
Parameter |
Finding |
Points |
---|---|---|
age of the patient |
< 70 years of age |
0 |
|
>= 70 years of age |
1 |
gender |
male |
0 |
|
female |
1 |
history of remote bleeding |
absent |
0 |
|
present |
1 |
history of recent bleeding |
absent |
0 |
|
present |
1 |
alcohol and/or drug abuse |
absent |
0 |
|
present |
1 |
diabetes mellitus |
absent |
0 |
|
present |
1 |
anemia |
absent |
0 |
|
present |
1 |
antiplatelet agent therapy |
absent |
0 |
|
present |
1 |
risk score =
= (0.49 * (points for age of the patient)) + (0.32 * (points for gender)) + (0.58 * (points for remote bleeding)) + (0.62 * (points for recent bleeding)) + (0.71 * (points for alcohol or drug abuse)) + (0.27 * (points for diabetes)) + (0.86 * (points for anemia)) + (0.32 * (points for antiplatelet agent therapy))
Interpretation:
• minimum score: 0
• maximum score: 4.17
• The higher the score the greater the risk of bleeding.
Risk Score |
Risk of Bleeding |
---|---|
<= 1.07 |
low |
1.08 to 2.18 |
moderate |
>= 2.19 |
high |
Purpose: To evaluate the risk of bleeding in an elderly patient with atrial fibrillation who is receiving warfarin using the bleeding risk model of Shireman et al.
Specialty: Hematology Oncology, Clinical Laboratory, Pharmacology, clinical
Objective: risk factors, failure handling and therapy escalation, adverse effects
ICD-10: R58,