Mulrow et al measured the burden of disease (BOD) on an elderly patient based on measurement of a list of conditions. This can be used to monitor the impact of disease over time. The authors are from the University of Texas Health Science Center and Audie L. Murphy Memorial Veterans Hospital in San Antonio, Texas.
Parameters (59):
valvular heart disease
ischemic heart disease
conduction defects and arrhythmias
cardiac failure
arterial hypertension
hypotension
arterial aneurysm
cerebrovascular disease
peripheral arterial disease (PAD)
thrombophlebitis
chronic lung disease
pulmonary embolism and/or infarct
chronic lung infection, non-bacterial
diabetes mellitus
hyperlipidemia
thyroid disease
dementia
intermittent confusion and/or combativeness
Parkinson’s disease
myelopathy
seizure disorder
cerebellar disorder
hemiparesis, hemiplegia, paraplegia
neuropathy
liver disease
gastrointestinal disease, non-rectal
gastrointestinal disease, rectal (including incontinence)
biliary and/or pancreatic disease
electrolyte disorders
kidney diseases
lower genitourinary disorders (urinary bladder, prostate, urethra)
eye disease
gynecological disorder
sexual dysfunction
arthritis
bone disease, including osteoporosis
nonspecific muscle pain or spasm, fibrositis
chronic pain syndrome
diffuse connective tissue disorder
anemia
malignancy, hematologic
malignancy, solid tumor
malignancy, skin
AIDS
depression
anxiety
psychosis or schizophrenia
sleep disorder
substance abuse, non-alcohol
substance abuse, alcohol
skin disorder, wounds and ulcers
skin disorder, other
infections
injuries
fractures
surgeries
syncope
headache
other
Severity |
Points |
none |
0 |
inactive |
1 |
mild |
2 |
moderate |
3 |
severe |
4 |
total score =
= SUM(points for all 59 items)
Interpretation:
• minimum score: 0
• maximum score: 236
• The higher the score the more severe the burden of illness.
Limitations:
• The classification of disease is uneven with vastly different diseases weighted equally.
• Some categories (like non-bacterial chronic lung infection) are suboptimal.
• Some disorders are not mentioned or else lumped under non-specific categories.
• Weighting is linear by disease severity but the burden is nonlinear.
• An inactive disease should be no burden to the patient.
Purpose: To determine a patient's burden of disease based on the study of Mulrow et al.
Objective: severity, prognosis, stage, disease progression
ICD-10: ,