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CALL Score of Ji et al for Predicting COVID-19 Progression

Description

Ji et al reported the CALL score for predicting progression for a patient with COVID-19. This can help to identify a patient who may require more aggressive management. The authors are from Fifth Medical Center of Chinese PLA General Hospital, Fuyang Second People's Hospital, Anhui Medical University and Humanity & Health Medical Group in Hong Kong.


Patient selection: COVID-19

 

Parameters:

(1) comorbidity (C) (hypertension, diabetes, cardiovascular disease, liver disease, asthma, chronic lung disease, HIV infection, malignancy)

(2) age in years (A)

(3) absolute lymphocyte counter in 10^9/L (L)

(4) serum LDH in U/L (L)

 

Parameter

Finding

Points

comorbidity

no

1

 

yes

4

age in years

<= 60 years

1

 

> 60 years

3

absolute lymphocyte

> 1.0 * 10^9/L

1

 

<= 1.0 * 10^9/L

3

serum LDH

<= 250 U/L

1

 

251 to 500 U/L

2

 

> 500 U/L

3

 

total score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 4

• maximum score 13

• A score > 6 was associated with an increased risk for progression.

 

Total Score

Progression

4 to 6

< 10%

7 to 9

10-40%

10 to 13

> 50%

 

Performance:

• The area under the ROC curve was 0.91.

• Grifoni et al found that the score did not perform particularly well for predicting disease progression, but it could identify patients at risk for in-hospital mortality (area 0.77).


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