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Carcinoma of Unknown Primary Site | Prognostic Model for Predicting Survival

Purpose: To evaluate a patient with an undifferentiated carcinoma of unknown primary site using the prognostic model of van der Gaast et al.

Description

van der Gaast et al developed a simple prognostic model for predicting survival in a patient with an undifferentiated carcinoma arising from an unknown primary site. The authors are from University Hospital Rotterdam-Dijkzigt and Erasmus University in Rotterdam.


 

Parameters:

(1) WHO (or ECOG performance scale)

(2) ratio of serum alkaline phosphatase to the upper limit of normal

 

ratio of serum alkaline phosphatase =

= (serum alkaline phosphatase) / (upper limit of normal reference range)

 

WHO Performance

Serum Alkaline Phosphatase Ratio

Prognostic Group

0

< 1.25

good

>= 1

< 1.25

fair

0

>= 1.25

fair

>= 1

>= 1.25

poor

 

 

Prognostic Group

Median Survival

Probability of 4 Year Survival

good

> 4 years

52%

fair

10 months

15%

poor

4 months

0% (0% at 14 months)

 


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Specialty

Objective

ICD-10