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Description

Antiarrhythmic drugs are classified based on their mode of action. Each class may be further divided.


Pharmacology

Class

HCN channel blocker

0

sodium channel blockers

1

beta-blocker and autonomic activators

2

potassium channel blockers

3

calcium channel blockers

4

other

miscellaneous

 

HCN channel blocker:

(1) ivabradine

 

Sodium channel blockers:

(1) quinidine (Ia)

(2) disopyramide (Ia)

(3) ajmaline (Ia)

(4) quinidine (Ia)

(5) procainamide (Ia)

(6) lidocaine (Ib)

(7) mexiletine (Ib)

(8) flecainide (Ic)

(9) propafenone (Ic)

(10) ranolazine (Id)

 

Beta-blockers and autonomic activators:

(1) propranolol (IIa)

(2) carvediol (IIa)

(3) atenolol (IIa)

(4) bisoprolol (IIa)

(5) betaxolol (IIa)

(6) metoprolol (IIa)

(7) isoproterenol (IIb)

(8) atropine (IIc)

(9) anisodamine (IIc)

(10) hyoscine (IIc)

(11) scopalamine (IIc)

(12) carbachol (IId)

(13) pilocarpin (IId)

(14) methacholine (IId)

(15) digoxin (IId)

(16) adenosine (IIe)

 

Potassium channel blockers (action potential prolongation):

(1) amiodarone (IIIa)

(2) sotalol (IIIa)

(3) dofetilide (IIIa)

(4) ibutilide (IIIa)

(5) nicorandil (IIIb)

(6) pinacidil (IIIb)

 

Calcium channel blockers:

(1) bepridil (IVa)

(1) verapamil (IVa)

(2) diltiazem (IVa)

(6) flecainide (IVb)

(7) propafenone (IVb)

 

Other antiarrhythmics:

(1) cations (potassium salt, magnesium salt)


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