Classification of the Chinese Group on the Study of Severe Hepatitis B (COSSH) for Hepatitis B Virus (HBV)-Related Acute-on-Chronic Liver Failure (ACLF)

Grade

Subgroup

1

a

renal failure alone

b

liver failure (with INR >= 1.5) alone and/or renal dysfunction and/or HE grade 1 or 2

c

single organ failure (coagulation, circulation, respiratory) and/or renal dysfunction and/or HE grade 1 or 2

d

cerebral failure plus kidney dysfunction

2

organ failure in 2 organ systems

3

organ failure in >= 3 organ systems

Grade

28 Day Mortality

90 Day Mortality

1

23%

36%

2

61%

74%

3

93%

100%