Clinical Features of Acquired Generalized Lipodystrophy (AGL, Lawrence Syndrome)

 

Synonyms: AGL, Lawrence Syndrome

 

Clinical features:

(1) generalized loss of subcutaneous fat

(2) onset during childhood or as an adult (normal fat distribution at birth and during infancy, onset usually before 30 years of age)

(3) diabetes with insulin resistance

(4) variable panniculitis (subcutaneous inflammatory nodules)

(5) variable intra-abdominal fat sparing

(6) hepatosplenomegaly

(7) acanthosis nigricans

(8) hyperphagia

(9) hirsutism

 

Risk factors:

(1) female gender

(2) autoimmune disease (juvenile dermatomyositis, autoimmune hepatitis, other)

 

Laboratory findings:

(1) hyperinsulinemia

(2) hypertriglyceridemia