Description

A patient with neuropsychiatric systemic lupus erythematosus (SLE) may develop a number of changes that can be seen on cerebral magnetic resonance imaging (MRI).


 

Sites evaluated:

(1) frontal lobes (cortical, juxtacortical, subcortical)

(2) parietal lobes (cortical, juxtacortical, subcortical)

(3) temporal lobes (cortical, juxtacortical, subcortical)

(4) occipital labes (cortical, juxtacortical, subcortical)

(5) cerebellum

(6) basal ganglia

(7) diencephalons

 

Parameters seen on the MRI:

(1) cortical atrophy

(2) micro-ischemic focal lesions (< 6 mm in diameter)

(3) macro-ischemic focal lesions (6 to 10 mm in diameter)

(4) large focal lesions (> 10 mm in diameter)

 

Features Seen on MRI

Diagnosis

no atrophy AND <= 2 micro AND no macro AND no large

normal

(mild atrophy OR 3 to 5 micro) AND no macro AND no large

mild changes

(moderate atrophy OR > 5 micro OR 1 or 2 macro) AND no large

moderate changes

severe atropy OR > 2 macro OR >= 1 large

severe changes

 


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