Common Toxicity Criteria (CTC) for Cardiac Arrhythmias Associated with Cancer Therapy

Description

The Common Toxicity Criteria (CTC) define adverse events following cancer therapy. It was designed for use in clinical trials of different therapeutic regimens.

Cardiac arrhythmias:

(1) conduction abnormalities (atrioventricular heart block)

(2) nodal or junctional arrhythmia

(3) palpitations in the absence of cardiac arrhythmia

(4) prolonged QTc interval (> 0.48 seconds)

(5) sinus bradycardia

(6) sinus tachycardia

(7) supraventricular arrhythmia (supraventricular tachyarrhythmia, atrial fibrillation, atrial flutter)

(8) vasovagal episode

(9) ventricular arrhythmia (premature ventricular contractions, bigeminy, trigeminy, ventricular tachycardia)

(10) other cardiac arrhythmia

NOTE: Syncope is graded under the Neurology criteria.

Arrhythmia	Finding	Grade
conduction abnormality	none	0
	asymptomatic, not requiring therapy (Mobitz type I second degree AV block, Wenckebach)	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy (Mobitz type II second degree AV block, third degree AV block)	3
	life-threatening (in conjunction with shock, syncope, CHF, hypotension, etc.)	4
nodal or junctional	none	0
	asymptomatic, not requiring therapy	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy	3
	life-threatening (in conjunction with shock, syncope, CHF, hypotension, etc.)	4
palpations	none	0
	present	1
prolonged QTc interval	none	0
	asymptomatic, not requiring therapy	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy	3
	life-threatening (in conjunction with shock, syncope, CHF, hypotension, etc.)	4
sinus bradycardia	none	0
	asymptomatic, not requiring therapy	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy	3
	life-threatening (in conjunction with shock, syncope, CHF, hypotension, etc.)	4
sinus tachycardia	none	0
	asymptomatic, not requiring therapy	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy	3
supraventricular	none	0
	asymptomatic, not requiring therapy	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy	3
	life-threatening (in conjunction with shock, syncope, CHF, hypotension, etc.)	4
vasovagal episode	none	0
	present without loss of consciousness	2
	present with loss of consciousness	3
ventricular	none	0
	asymptomatic, not requiring therapy	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy	3
	life-threatening (in conjunction with shock, syncope, CHF, hypotension, etc.)	4
other arrhythmia	none	0
	asymptomatic, not requiring therapy	1
	symptomatic, not requiring therapy	2
	symptomatic, requiring therapy	3
	life-threatening (in conjunction with shock, syncope, CHF, hypotension, etc.)	4

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Common Toxicity Criteria (CTC) for Cardiac Arrhythmias Associated with Cancer Therapy

Description

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