Common Toxicity Criteria (CTC) for Ocular and Visual Adverse Events Associated with Cancer Therapy

Type of Adverse Event

Finding

Grade

cataract

asymptomatic

1

partial visual loss

2

visual loss requiring treatment or interfering with function

3

conjunctivitis

abnormal ophthalmologic changes but asymptomatic

1

symptomatic without visual impairment

1

interferes with function but does not interfere with activities of daily living

2

interferes with activities of daily living

3

dry eye

mild, not requiring treatment

1

moderate or requiring artificial tears

2

glaucoma

increase in intraocular pressure but no visual loss

1

increase in intraocular pressure with retinal changes

2

visual impairment

3

unilateral or bilateral loss of vision (blindness)

4

keratitis

abnormal ophthalmologic changes but asymptomatic

1

symptomatic without visual impairment

1

symptomatic and interfering with function but not with activities of daily living

2

interferes with activities of daily living

3

unilateral or bilateral loss of vision (blindness)

4

tearing

mild, not interfering with function

1

symptomatic and interfering with function but not with activities of daily living

2

interferes with activities of daily living

3

blurred vision

symptomatic and interfering with function but not with activities of daily living

2

interferes with activities of daily living

3

double vision

symptomatic and interfering with function but not with activities of daily living

2

interferes with activities of daily living

3

flashing lights, floaters

mild, not interfering with function

1

symptomatic and interfering with function but not with activities of daily living

2

interferes with activities of daily living

3

night blindness

abnormal electroretinography but asymptomatic

1

interferes with function but not with activities of daily living

2

interferes with activities of daily living

3

photophobia

symptomatic and interfering with function but not with activities of daily living

2

interferes with activities of daily living

3

other disturbance

mild

1

moderate

2

severe

3

unilateral or bilateral loss of vision (blindness)

4