Complication Risk Scores of Vitrano et al for a Patient with Thalassemia: Transfusion-Dependent Thalassemia (TDT)

Description

Vitrano et al reported three scores for evaluating a patient with a thalassemia syndrome. One score evaluates a patient with a transfusion-dependent phenotype. The authors are from multiple institutions in Italy, Iran, Egypt, Pakistan, Oman, South Africa and Saudi Arabia.

Patient selection: transfusion-dependent thalassemia

Outcome: one or more complications

Parameters:

(1) age in years

(2) hemoglobin (in g/L in the paper, but may be g/dL)

(3) serum AST in IU/L

(4) serum ALT in IU/L

(5) left ventricular ejection fraction (LVEF) in percent (from 0 to 100)

Parameter	Points
age in years	0.104 * (age)
hemoglobin	0.499 * (Hgb)
serum AST	0.008 * (AST)
serum ALT	0.017 * (ALT)
LVEF	-0.134 * (LVEF)

risk score =

= SUM(points for all of the parameters) + 0.825

Risk Score	Risk Group
< 0.39	low
0.39 to 0.80	intermediate
0.81 to 0.94	high
>= 0.95	very high

Performance:

• The area under the ROC curve is 0.83.

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Complication Risk Scores of Vitrano et al for a Patient with Thalassemia: Transfusion-Dependent Thalassemia (TDT)

Description

Specialty