Comprehensive Cytogenetic Scoring System of Schanz et al for Primary Myelodysplastic Syndrome or Oligoblastic Acute Myeloid Leukemia

Description

Schanz et al reported a comprehensive scoring system based on cytogenetics for patients with primary myelodysplasia (MDS) or oligoblastic acute myeloid leukemia (AML). This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions from around the world.

Patient selection: primary myelodysplastic syndrome or oligoblastic acute myeloid leukemia

Parameters:

(1) total number of cytogenetic abnormalities

(2) specific cytogenetic abnormalities

Total Number	Specific Cytogenetic Abnormalities	Prognosis
>= 4	NA	very poor
3	NA	poor
2	del(5q) OR -7	poor
2	del(7q)	good
2	other	intermediate
1	inv(3) OR t(3q) OR del(3q) OR -7	poor
1	del(11q) OR -Y	very good
1	del(5q) OR del(12p) OR del(20q)	good
1	del(7q) OR +8 OR i(17q) OR +19	intermediate
1	independent clones	intermediate
1	other	intermediate
0 (none)	NA	good

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Description

Specialty

ICD-10