Eryoptosis refers to erythrocyte self-destruction in a process similar to apoptosis. It may be decreased in certain circumstances.
Manifestations:
(1) reduction in red cells showing changes of eryoptosis (microspherocytes, blebs, etc)
(2) reduced leakage of calcium ion into the erythrocyte
Drugs and chemical associated with decreased eryoptosis:
(1) erythropoietin
(2) nitroprusside (nitric acid donor)
(3) amitriptyline
(4) adenosine
(5) caffeine
(6) catecholamines
(7) flufenamic acid
(8) urea
(9) papanoate (nitric oxide donor)
Biochemical factors associated with decreased erytoptosis:
(1) AMP-activated kinase (AMPK)
(2) cGMP-dependent protein kinase type I (cGKI)
(3) loss of phosphoinositide-dependent kinase (PDK1)
(4) loss of JAK3
(5) loss of taurine transporter (TAUT)
(6) loss of PAF receptor
(7) loss of TRPC6
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Specialty: Hematology Oncology
