Contraindications to the use of
extended interval aminoglycoside dosing
(1) hypersensitivity to aminoglycosides (avoid aminoglycosides entirely)
(2) infants and children <= 12 years old
(3) severely debilitated, elderly patients
(4) pregnancy
(5) postpartum state (within 2 months of delivery)
(6) breastfeeding
(7) impaired renal function (creatinine clearance <= 20 mL/min)
(8) dialysis
(9) severe burns > 20% body surface area (rapid excretion)
(10) cystic fibrosis (rapid excretion)
(11) Enterococcal endocarditis
(12) Pseudomonas aeruginosa infection (resistance)
(13) ascites
(14) cirrhosis
(15) neutropenia (absolute neutrophil count < 1,000 per µL)
(16) significant obesity
(17) patients with a history of hearing loss
