Absolute contraindications:
(1) active internal hemorrhage
(2) recent hemorrhagic stroke, within past 3 months
(3) recent intracranial or intraspinal surgery, within past 2 months
(4) recent severe head trauma, within past 2 months
(5) trauma with an increased risk of life-threatening bleeding
(6) presence of epidural catheter
(7) intracranial neoplasm or mass lesion
(8) evidence of cerebral herniation
Relative contraindications:
(1) concurrent therapy with heparin (>= 15 units per kg per hour)
(2) INR > 3.0
(3) platelet count < 30,000 per µL (even if higher after platelet transfusion)
(4) recent gastrointestinal bleeding, within past 6 weeks
(5) recent thrombolytic therapy, within 3 days
(6) recent oral anticoagulant therapy, within 7 days
(7) recent glycoprotein IIb/IIIa inhibitor therapy, within 7 days
(8) recent administration of aspirin (> 650 mg per day) or other platelet inhibitor, within 7 days
(9) recent ischemic stroke, within 3 months
(10) intracranial arteriovenous malformation
(11) intracranial aneurysm
(12) known bleeding diathesis
(13) any condition in which bleeding represents a significant hazard
(14) any condition in which bleeding may be difficult to manage because of its location
