Scheiner et al reported the CRAFITY score, which can help to determine if immunotherapy is appropriate for a patient with hepatocellular carcinoma. The authors are from multiple institutions in Europe,
CRAFITY is an acronym for CRP, AFP and immunotherapy.
Patient selection: hepatocellular carcinoma
Parameters:
(1) serum CRP in mg/dL
(2) serum AFP in ng/mL
Parameter
Finding
Points
serum CRP
< 1 mg/dL
0
>= 1 mg/dL
1
serum AFP
< 100 ng/mL
0
>= 100 ng/mL
1
total score =
= SUM(points for both parameters)
Interpretation:
• minimum score: 0
• maximum score: 2
• A low CRAFITY score had a better response to immunotherapy.
Total Score
Risk Category
Median Overall Survival
0
CRAFITY-low
27.6 months
1
CRAFITY-intermediate
11.3 months
2
CRAFITY-high
6.4 months
Other factors impacting overall survival:
(1) Child-Pugh class (A vs B/C)
(2) ECOG performance status ( 0 vs 1+)
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