Description

Certain criteria can help to identify failure during therapy for an acute bacterial skin and skin structure infection (ABSSSI).


Patient selection: started appropriate therapy for an ABSSSI

 

Clinical failure - one or more of the following within 45 days (alternatively 30 days) of hospital discharge or completion of initial therapeutic protocol:

(1) treatment failure

(2) recurrence

(3) readmission for ABSSSI

 

Treatment failure - one or both of the following more than 5 days after starting therapy because of inadequate clinical response:

(1) change in antibiotic therapy because of poor clinical response or clinical progression

(2) unplanned drainage procedure

where:

"Change in antibiotic therapy" does not include (1) a change in route of administration (from intravenous to oral) or (2) change due to adverse drug effect (allergy, intolerance, etc).

 

Recurrence was defined as re-initiation of antibiotic therapy for skin infection after completion of the initial treatment course.


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