Alarcon et al reported criteria for the diagnosis of congenital cytomegalovirus (CMV) infection. The authors are from Oxford University Hospitals NHS Foundation Trust, Imperial College London, Sant Joan de Deu University Hospital and La Paz University Hospital.
Patient selection: neonate
The diagnosis of congenital cytomegalovirus (CMV) requires one or more of the following during the first 2 weeks of life:
(1) isolation of CMV from urine or blood
(2) isolation of CMV viral DNA in urine or blood
(3) detection of specific CMV IgM antibody in blood
(4) detection of CMV antigen in blood
The infection is symptomatic if one or more of the following is present:
(1) intrauterine growth retardation (birthweight smaller than 2 SD below mean)
(2) petechiae
(3) hepatomegaly >= 2 cm
(4) splenomegaly >= 2 cm
(5) microcephaly (head circumference smaller than 2 SD below mean)
(6) sensorineural hearing loss (hearing threshold >= 20 dB by auditory brainstem responses)
(7) chorioretinitis
(8) thrombocytopenia (platelet count < 100,000 per µL)
(9) hepatitis or cholestasis (serum total bilirubin > 3 mg/dL and/or elevated ALT)
(10) intracranial calcifications
