The enhanced fibrinolytic type of DIC is seen in aortic aneurysms, abruptio placentae, acute promyelocytic leukemia, prostate cancer and hemangiomas.
Prerequisites - both of the following:
(1) thrombin-antithrombin complex (TAT) >= 20 µg/L
(2) plasmin-alpha-2 plasma complex (PIC) >= 10 µg/L
2 or more of the following laboratory findings:
(1) fibrin degradation products (FDP) >= 80 µg/mL
(2) fibrinogen < 100 mg/dL
(3) increased ratio of FDP to D-dimer
where:
• An increased FDP to D-dimer ratio is the same as a decreased D-dimer to FDP ratio.
For a patient with enhanced fibrinolytic DIC, bleeding may be severe if there is also:
(1) thrombocytopenia with platelet count < 50,000 per µL
(2) decreased alpha-2 plasmin inhibitor (alpha-2 PI) activity < 50%
