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Criteria of Cheson et al for Complete or Partial Remission After Therapy for Myelodysplastic Syndrome (International Working Group to Standardize Response Criteria)

Description

An international working group was formed to standardize response criteria for therapy of myelodysplastic syndromes (MDS). These included criteria for a complete or partial remission to therapy. The authors are from multiple institutions in Europe and the United States.


 

Duration of findings: at least 2 months (8 weeks)

 

Features of a remission (complete or partial) - all of the following:

(1) hemoglobin > 11 g/dL

(2) platelet count > 100,000 per µL

(3) absolute neutrophil count >= 1,500 per µL

(4) no circulating blasts in peripheral blood

(5) no blood product transfusion

(6) no growth factor therapy

Finding

Complete Remission

Partial Remission

percentage blasts

< 5% (normal) AND

decreased >= 50% from pretreatment levels OR

evidence of MDS

AND no dysplasia with normal maturation in all cell lines

OR less advanced FAB classification

 

 

Percent Erythroid Precursors

Formula for Blast Percent

< 50%

(number blasts) / (100 nucleated cells) * 100%

>= 50%

(number blasts) / (100 nonerythroid cells) * 100%

 


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Specialty

ICD-10