Criteria:
(1) >= 1 major depressive episodes
(2) no spontaneous hypomanic episodes
(3) no spontaneous manic episodes
(4) presence of findings in Group 1 and 2 matching one of the following patterns
|
Group 1 (2 items)
|
Group 2 (9 items)
|
|
2
|
>= 1
|
|
1
|
>= 2
|
|
0
|
>= 6
|
Group 1:
(1) one or more first degree relatives with bipolar disorder
(2) antidepressant-induced hypomania or mania
Group 2:
(1) hyperthymic personality (with nondepressed state at baseline)
(2) recurrent (> 3) episodes of major depression
(3) brief major depressive episodes (averaging < 3 per month)
(4) atypical depressive symptoms (based on DSM-IV criteria)
(5) major depressive episode with psychosis
(6) first major depressive episode when < 25 years old
(7) postpartum depression
(8) antidepressant "wear-off" (respond acutely to antidepressants but these do not work for prophylaxis)
(9) lack of response to multiple (>= 3) antidepressant treatment trials at adequate doses
where:
• Hyperthymic personality indicates excessive emotion.
• I have not limited postpartum depression to females in the implementation since fathers can experience depression after the birth of a child.
