Criteria of Mana for Disease Activity in Sarcoidosis

Clinical findings:

(1) erythema nodosum or skin granulomas

(2) polyarthralgia or polyarthritis

(3) respiratory symptoms (cough, dyspnea)

(4) fever

(5) uveitis

(6) hepatosplenomegaly

(7) parotid enlargement

(8) upper respiratory tract involvement

(9) neurologic symptoms

Laboratory findings:

(1) elevated serum angiotensin-converting enzyme (ACE) concentration

(2) elevated serum calcium (> 10.5 mg/dL, or 2.62 mmol/L)

Imaging findings:

(1) mediastinal lymphadenopathy

(2) pulmonary infiltration

(3) increased liver uptake on gallium-67 scan

Other findings:

(1) positive Kveim test

(2) lymphocytic alveolitis (increased lymphocytes in bronchoalveolar lavage)

(3) decreased forced vital capacity (< 80% of predicted)

(4) decreased carbon monoxide diffusing capacity (< 80% of predicted)

Disease activity can be assessed based on change in any of the listed criteria.