Patient: acute bacterial skin and skin structure infection (ABSSSI)
Timings of evaluation:
(1) early (48 to 72 hours after starting therapy)
(2) late (7 to 14 days after end of therapy)
Criteria for early treatment success:
(1) >= 20% reduction in area of physical findings from baseline
(2) clinical assessment as improving or stable
where:
• Physical findings may be erythema alone (used in ESTALISH-1 trial) or maximal extent of erythema, induration or edema (used in ESTABLISH-2).
• Area is based on multiplying maximal dimension by widest perpendicular measure (an ellipse might be more accurate).
Criteria for late clinical cure:
(1) clinical assessment as resolved or nearly resolved
(2) no further antibiotic therapy required
