Criteria of Tavassoli for Atypical Papilloma and Carcinoma Arising in a Papilloma

Tavassoli listed criteria for reporting atypical cellular proliferations arising in a breast papilloma.

Parameters:

(1) type of atypical cellular proliferation arising in the papilloma

(2) percent of papilloma involved

Type of Atypical Cellular Proliferation	Percent of Papilloma Involved	Appropriate Term
low grade nonnecrotic ductal carcinoma in situ (Grade 1 DCIS)	< 33%	atypical papilloma
low grade nonnecrotic ductal carcinoma in situ (Grade 1 DCIS)	33 to 89%	carcinoma in situ arising in a papilloma
low grade nonnecrotic ductal carcinoma in situ (Grade 1 DCIS)	90 to 100%	papillary carcinoma in situ
necrotic and/or high grade ductal carcinoma in situ (Grade 2 or 3 DCIS)	any	carcinoma in situ arising in a papilloma
highly atypical cell population with or without abundant mitotic activity in a solid or cribriform pattern over a persistent myoepithelial cell layer	any	carcinoma in situ arising in a papilloma
anaplastic cell proliferation	any	carcinoma arising in a papilloma

The presence of a pathologic process in adjacent ducts has a greater influence on outcome.

An atypical papilloma or carcinoma in situ arising in a papilloma should be totally excised with an adequate rim of uninvolved tissue.

To read more or access our algorithms and calculators, please log in or register.