Efavirenz Dose Reduction in HIV-1 Infected Patient Based on CYP2B6 Genotype

Purpose: To evaluate an HIV-infected patient for CYP2B6 genotype and its effect on efavirenz dose adjustment.

Info MyLikes MyPaths

Evaluation

Are you evaluating an HIV-infected patient who is being treated with efavirenz?

Yes

CYP2B6 genotype

Number of *6 alleles (enter 0, 1 or 2)

Number of *26 alleles (enter 0, 1 or 2)

Results

Please fill out required fields.

Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Number of problems alleles

Is there an obvious problem with the data as entered?

Is the patient at risk for efavirenz accumulation and CNS toxicity with the standard dose?

Caution: A qualified health practitioner should verify all results.
Keep patient data confidential and comply with all legal requirements.

Please visit our website Medicalalgorithms.com for Description and Interpretation and further algorithms you may want to consider in the next steps of your evaluation. All information should be verified by a qualified health professional, and all use is subject to Medicalalgorithms.com Terms and Conditions. © Copyright Medicalalgorithms.com Limited

Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
Laboratory Tests
- Determining Isoniazid Acetylation Phenotype Based on Measurement of Urinary Isoniazid and Acetylisoniazid
- ABCB1 Polymorphism Test Prior to Therapy with Docetaxel or Irinotecan
Other Testing
- Methotrexate Toxicity & MTHFR (Methelenetetrahydrofolate Reductase) C677T Polymorphism
- Impact of CYP2C19 Phenotype on Clopidogrel Response
Criteria For Diagnosis
- Warfarin for Polymorphism in Cytochrome P450 (CYP) CYP2C9 | Medical Algorithm
Severity, Prognosis, Stage
- Predict Severe Toxicity Associated with Fluorouracil (5-FU) Therapy

Therapy

Selection
Pharmacogenetics

Monitoring

Response To Therapy
Adverse Effects
- Methotrexate Toxicity & MTHFR (Methelenetetrahydrofolate Reductase) C677T Polymorphism
- HLA Screening to Identify Asian Patient at Risk for Carbamazepine-Associated Stevens-Johnson Syndrome

Specialty

Toxicology
Emergency Medicine
Critical Care
Genetics

Objective

dosage adjustments
adverse effects

ICD-10

T37.5 - Poisoning, antiviral drugs

Info

Purpose: To evaluate an HIV-infected patient for CYP2B6 genotype and its effect on efavirenz dose adjustment.

Specialty: Toxicology, Emergency Medicine, Critical Care, Genetics

Objective: dosage adjustments, adverse effects

ICD-10: T37.5,

Save Data

Identifier

Enter 1 to 5 characters as ID

Email

Your registered email

Other

Email to

Please separate multiple email IDs with comma (,)

Consult Report

Identifier

Enter 1 to 5 characters as ID

Add to MyPath

Select path

New path