The original DAS 3 and 4 variable scores of van der Heijde et al can be modified to use C-reactive protein (CRP) in place of the erythocyte sedimentation rate (ESR).
Parameters:
(1) Ritchie score – range 0 to 46
(2) number of swollen joints- range 0 to 44
(3) C-reactive protein (CRP) in mg/L
(4) general health status using a 100 mm visual analogue scale (VAS) – range 0 to 100, with 100 indicating worst possible health imaginable
DAS score using 4 variables =
= (0.53938 * (SQRT(Ritchie score))) + (0.06465 * (number of swollen joints)) + (0.17 * LN(CRP+1)) + (0.00722 * (general health VAS score)) + 0.45
DAS score using 3 variables =
= (0.53938 * (SQRT(Ritchie score))) + (0.06465 * (number of swollen joints)) + (0.17 * LN(CRP+1)) + 0.65
where:
• Adding 1 to the CRP avoids LN(0).
Interpretation:
• minimum score: 0 (no disease activity)
• maximum score: around 8.16
• The higher the score, the greater the disease activity.
Purpose: To evaluate disease activity in a patient with rheumatoid arthritis using the disease activity score (DAS) modified to use CRP.
Specialty: Immunology/Rheumatology
Objective: clinical diagnosis, including family history for genetics, laboratory tests, criteria for diagnosis, comorbid conditions
ICD-10: M05, M06, M48.0,