Differential Diagnosis of Hemorrhagic Disease of the Newborn (HDNB)

 

Hereditary coagulation factor defects:

(1) hemophilia A or B (Factor 8 or 9 deficiency)

(2) von Willebrand’s disease

 

Acquired coagulation factor defects:

(1) coumarin or heparin exposure (accidental, intentional)

(2) liver disease

 

Thrombocytopenia:

(1) hereditary platelet defects

(2) immune thrombocytopenic purpura (ITP)

(3) neonatal isoimmune thrombocytopenia

(4) congenital leukemia

(5) bone marrow hypoplasia or aplasia

 

Multifactorial:

(1) disseminated intravascular coagulation (DIC)

(2) infection or sepsis