A number of mutations in different can result in severe congenital neutropenia (SCN).
Type
Gene
Location
Inheritance
1
ELANE
19p13.3
auto dominant
2
GF11
1p22.1
3 (Kostmann)
HAX1
1q21.3
auto recessive
4
G3PC3
17q21.31
5
VPS45
1q21.2
6
JAGN1
3p25.3
X-linked
WAS
X
X linked
Other hereditary disorder may be associated with neutropenia, so these need to be considered when evaluating the patient.
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Specialty: Hematology Oncology
