Adams et al identified pathologic changes associated with diffuse axonal injury (DAI) following traumatic head injury (TBI). These correlate with the severity of the injury. The authors are from the University of Glasgow,
Parameters:
(1) histologic evidence of axonal injury in the white matter of the cerebral hemispheres
(2) histologic evidence of axonal injury in the white matter of the corpus callosum
(3) histologic evidence of axonal injury in the white matter of the brainstem
(4) histologic evidence of axonal injury in the white matter of the cerebellum
(5) focal gross or microscopic lesion(s) of the corpus callosum
(6) focal gross or microscopic lesion(s) in the dorsolateral quadrant(s) of the rostral brainstem (midbrain and upper pons)
Pathologic Findings
Grade
no evidence of axonal injury
0
histologic evidence of axonal injury in cerebral hemispheres, corpus callosum, brainstem and/or cerebellum
1
focal lesion in the corpus callosum
2
focal lesion in the rostral brainstem
3
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