Discriminant Score of Marti et al for Evaluating a Patient with Idiopathic Dilated Cardiomyopathy for Heart Transplantation

Patient selection (page 746):

(1) Idiopathic dilated cardiomyopathy diagnosed by echocardiography, with left ventricular dilatation and reduced left ventricular ejection fraction, in the absence of angiographic evidence of coronary artery disease.

(2) All patients had >= 1 episode of heart failure requiring hospital admission.

(3) Heart failure was NYHA functional class III or IV and refractory to medical therapy.

(4) About a fifth had alcoholic cardiomyopathy.

Parameters:

(1) mean right atrial pressure in mm Hg

(2) cardiac index in liters per minute per square meter BSA

(3) New York Heart Association Functional Class (NYHA) from 1 to 4

discriminant score =

= (0.100072 * (mean right atrial pressure)) - (0.66007 * (cardiac index)) + (0.38627 * (NYHA functional class)) + 0.12005

Interpretation:

• Patients who survived had a mean discriminant score of (-0.46) +/- 1.0 (range for +/- 2 SD is (-2.46) to 1.54; value for mean + 1 SD is 0.54).

• Patients who died had a mean discriminant score of 1.42 +/- 0.92 (range for +/- 2 SD is (-0.42) to 3.26; value for mean minus 1 SD is 0.50).

Using this information, one possible interpretation table would be: