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Disease Severity Scoring System (DSSS) of Cappellini et al for Non-Transfusion-Dependent Thalassemia (NTDT): Cardiovascular Status

Description

Cappellini et al for developed a Disease Severity Scoring System (DSSS) for patients with non-transfusion-dependent thalassemia (NTDT). One component deals with the cardiovascular status.The authors are from the University of Milan, University College London, American University of Beirut, University of Athens, Mahidol University (Bangkok) and the University of Cagliari.


 

Patient selection: non-transfusion-dependent thalassemia (NTDT)

 

Parameters:

(1) left ventricular ejection fraction (LVEF, current or within past 3 months)

(2) cardiac T2 on MRI (current or within past 3 months)

(3) heart failure (current or within past 6 months)

(4) cardiac arrhythmias

(5) thrombosis

 

Parameter

Finding

Points

LVEF

>= 55%

0

 

< 55%

1

cardiac T2

> 20 ms

0

 

10 to 20 ms

1

 

6 to 9.9 ms

2

 

< 6 ms

3

heart failure

none

0

 

NYHA Class I

1

 

NYHA Class II

2

 

NYHA Class III

3

 

NYHA Class IV

4

arhythmias

absent

0

 

any history

1

 

current

2

thrombosis

absent

0

 

any history

1

 

current

2

 

where:

• The response for LVEF and NYHA class should be consistent.

 

subscore for cardiovascular status =

= SUM(points for all 5 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 12

 


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