An endocervical adenocarcinoma and an endometrial adenocarcinoma may resemble each others in cytology or curettage specimens. The tumors can be distinguished based on a number of factors.
Parameter
Endocervical Adenocarcinoma
Endometrial Adenocarcinoma
nucleoli
multiple
single, central
HPV by ISH
positive
negative
p16
positive
negative
CEA
positive
weak positive to negative
vimentin
negative
positive
estrogen receptor (ER)
negative
positive
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