Inada and Inagaki reported dose equivalence for drugs used as anxiolytics, sedatives and hypnotics in Japan. The authors are from Seiwa Hospital and Aoyama Gakuin University in Japan.
Drug
Equivalent Dose
alprazolam
0.8
bromazepam
2.5
chlordiazepoxide
10
clobazam
10
clonazepam
0.25
clorazepate
7.5
clotiazepam
10
cloxazolam
1.5
diazepam
5
etizolam
1.5
fludiazepam
0.5
flutazolam
15
flutoprazepam
1.67
loflazepate
1.67
lorazepam
1.2
medazepam
10
mexazolam
1.67
oxazepam
15
oxazolam
20
prazepam
12.5
tandospirone
25
tofisopam
125
Drug
Equivalent Dose
amobarbital
50
barbital
75
bromvalerylurea
500
brotizolam
0.25
butoctamide
500
chloral hydrate
250
estazolam
2
eszopiclone
2.5
flunitrazepam
1
flurazepam
15
haloxazolam
5
lormetazepam
1
nimetazepam
5
nitrazepam
5
Passiflora extract
100
pentobarbital
50
phenobarbital
15
quazepam
15
rilmazafone
2
secobarbital
50
triazolam
0.25
zolpidem
10
zopiclone
7.5
where:
• Butoctamide is no longer available in Japan.
multiple of the equivalent dose =
= (actual dose) / (equivalent dose)
To convert to another drug in the table:
dose for new drug =
= (multiple of the equivalent dose for previous drug) * (equivalent dose for new drug)
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